With artificial variation in drug release profile, drug release at a specific site could be achieved. Nanosystems were extensively employed to incorporate active constituents, including nanospheres, nanocapsules, niosomes, liposomes, and dendrimers. Dosage forms were designed according to their usage, specificity, and stimulus-based. One of the basic advantages of incorporating the drug into the carrier system is to protect the drug during its overall stay within the body, starting from its point of administration until it reaches a specific site of action. Lipid-based dosage forms, including microspheres and microcapsules, tend to avoid drug leakage after its administration. The release of the medicinal agents from the carrier system depends upon the rate and shape of kinetics, the viscosity of the media, and the drug release profile. The system’s efficiency depends on how much the system could bear the protective barrier. As per the report published in 2015, it was estimated that $178 million were spent on drug delivery systems, which could be increased to $310 billion by the year 2025.īy definition, the carrier means a system capable of incorporating a specific quantity of medicinal agents to increase their efficiency, selectivity, and bioavailability. ĭrug carriers were used to incorporate nutraceutical, cosmeceutical, and pharmaceutical formulations. Dextroamphetamine sulfate was the first manufactured by Kline, Smith, and French as sustained release products using the Spansule method. From the start of the 1940s to the 1990s, synthetic and semisynthetic polymers were used for enteric coating. Fraser, in 1883, started to fabricate molded tablets in a completely new concept that we use today. Fuller from New York, for the first time, suggested the concept of loading these molds with medicated milk sugar. Henry Bower and John Wyeth built an advanced machine that was not only more advanced than the previous one but also reduced the cost of producing tablets. The Brockedon method of tablet compression was used by Philadelphian Jacob Dunton to formulate tablets of different formulations, including quinine. In 1871, Messrs Newbery had purchased Professor Brockedon’s business. These tablets were hard, and no reference was found concerning their disintegration time and solubility. Professor Brockedon, 1844 in England, developed the first compressed tablets. This device compresses the powder without using adhesive into tablets. William Brockedon made a machine that can formulate lozenges and pills with the help of pressure on suitable dies. In medieval times, pills were coated using slippery substances obtained from plants. Roman scholars termed Pills as pilula (little ball). In ancient Greece, medicines were termed katapotia. Pills were made of simple hand-using ingredients like spices or plant powders. The pills were made from bread dough, grease, and honey. The first source of pills in ancient Egypt was recorded to be written on papyruses. At the end, some pharmaceutical applications were also discussed.Īround 1500 BCE, the first reference to the term pill as a solid dosage form came into existence. This review delivers a brief review on film coating in solid dosage form, which includes tablets, with a focus on the polymers and processes used in the coating. The efforts produced by computational modeling or experimental evaluation not only save cost in optimizing the coating process but also saves time. Meanwhile, computational modeling and experimental evaluation were actively used to predict the impact of the operational parameters on the final product quality and optimize the variables in tablet coating. During the process of film coating, several inter-and intra-batch uniformity of coated material on the tablets is considered a critical point that ensures the worth of the final product, particularly for those drugs that contain an active medicament in the coating layer. Although different techniques were employed for coating purposes, which may be based on the use of solvents or solvent-free, each of the methods used has its advantages and disadvantages, and the techniques need continued modification too. As tablet coating is a process driven by technology, it relies on advancements in coating techniques, equipment used for the coating process, evaluation of coated tablets, and coated material used. It increases the value of solid dosage form, administered orally, and thus meets diverse clinical requirements. Coating the solid dosage form, such as tablets, is considered common, but it is a critical process that provides different characteristics to tablets.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |